Are there any interactions with medications? Dosing considerations In foods, cranberry fruit is used in cranberry juice, cranberry juice cocktail, jelly, and sauce.
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Taking cranberry along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking cranberry, talk to your healthcare provider if you take any medications that are changed by the liver. Some medications that are changed by the liver include amitriptyline (Elavil), diazepam ( Valium ), zileuton (Zyflo), celecoxib ( Celebrex ), diclofenac (Voltaren), fluvastatin ( Lescol ), glipizide ( Glucotrol ), ibuprofen ( Advil, Motrin ), irbesartan ( Avapro ), losartan ( Cozaar ), phenytoin ( Dilantin ), piroxicam ( Feldene ), tamoxifen (Nolvadex), tolbutamide ( Tolinase ), torsemide ( Demadex ), warfarin (Coumadin), and others.
Cranberry juice dangerous with heart drug. Heart disease patients in the UK taking the blood thinning drug warfarin have been warned to avoid cranberry juice, after reports that the drink increases the drug's potency. They have previously been found to interact with many other drugs too.
Heart disease patients in the UK taking the blood thinning drug warfarin have been warned to avoid cranberry juice, after reports that the drink increases the drug's potency.
This week has seen reports from both sides of the Atlantic warning of the potentially dangerous interactions between natural remedies and prescription medication.
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In the US, a study published in JAMA found that the herb St Johns wort, taken to treat depression and anxiety, could interfere with up to 50 per cent of medications taken by Americans, owing to its effects on CYP3A4 enzymes.
J Pharm Pharm Sci. 2013;16(2):289-303. Cranberry juice ingestion and clinical drug-drug interaction potentials; review of case studies and perspectives.
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Cranberry juice is a popular beverage with many health benefits. It has anthocyanins to supplement dietary needs. Based on in vitro evidence cranberry juice is an inhibitor of CYP enzymes and at higher amounts as potent as ketoconazole (CYP3A) and fluconazole (CYP2C9). There is, however, a discrepancy between in vitro and in vivo observations with respect to a number of substrates (cyclosporine, warfarin, flurbiprofen, tizanidine, diclofenac, amoxicillin, ceflacor); with the exception of a single report on midazolam, where there was a moderate increase in the AUC of midazolam in subjects pre-treated with cranberry juice.
Learn about side effects, drug interactions, dosages, warnings, and more. Cranberry juice cocktail (26% cranberry juice): 10-16 oz/day orally; Cranberry juice:.
Diabetes : Clinical studies show NO improvement in fasting blood glucose, HbA1c, fructosamine, triglyceride, HDL cholesterol, or LDL cholesterol levels in patients with type 2 diabetes.
Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediay.
What Are Warnings and Precautions for Cranberry?
There is no reliable evidence that shows effectiveness for treating urinary tract infection (UTI).
If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them.
The product labeling of warfarin (Coumadin) lists a large number of drugs that can potentially interact with it and alter a patient's anticoagulant.
The prospective study is limited by a design that may not reflect the typical consumption of cranberry juice by all patients. Additional studies are needed with the chronic administration of higher doses of cranberry juice to determine its potential to alter warfarin response. Insufficient data are available at this time to evaluate the potential mechanism of the interaction between cranberry juice and warfarin. As with other purported warfarin interactions, several case reports suggest that cranberry juice may enhance the anticoagulant effect of warfarin.